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Database - Alliance francophone pour l'accouchement respecté (AFAR)
Created on : 17/11/2004
Modified on : 1/12/2007

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Author(s) :

Tranquilli AL, Giannubilo SR, Dell’Uomo B, Grandone E.

Bibliographical entry (without author) :

Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors.
European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;117(2):144-147.

Year of publication :


Résumé (français) :

Abstract (English):

Objective: To determine to what extent adverse pregnancy outcomes are associated with thrombophilia.

Study design: We studied 31 women who had HELLP syndrome, placental abruption, fetal growth restriction or unexplained stillbirth (study group), matched with 12 controls. All women were tested for: Factor V, Prothrombin, methylenetetrahydrofolate reductase gene (MTHFR) mutations; for Protein C, S and Antithrombin III deficiencie; for lupus anticoagulant. Correlation with 24 h BP monitoring and uterine Doppler velocimetry indexes at 22–24 weeks’ gestation was performed.

Results: Women with multiple thrombophilic factors had a significant lower birth weight (1568.33±146.8 g versus 2546.45±438 g), higher 24 h mean diastolic blood pressure at second trimester (76.3±12.5 mmHg versus 65.2±7.8 mmHg) and higher RI of uterine arteries (0.69±0.05 versus 0.50±0.15) than women with single thrombophilic factor.

Conclusion: Multiple thrombophilic factors carry a major additional risk for adverse maternal and fetal outcomes and correlate well with placental maladaptation as indicated by uterine Doppler velocimetry and 24 h BP monitoring.

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Keywords :

foetus growth ; eclampsia (pre-) ; low birth weight

Author of this record :

Cécile_Loup — 17/11/2004

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