=> [Français]
=> [Português]

Database - Alliance francophone pour l'accouchement respecté (AFAR)

Record ID : 1930
Created on : 30/03/2006
Modified on : 2/12/2007

Modify this record
Do not follow this link unless you know the admin password!

URL of this record : http://afar.info/id=1930

=> hard

Author(s) :

Li XM, Wan J, Xu CF, Zhang Y, Fang L, Shi ZJ, Li K.

Year of publication :

2004

Bibliographical entry (without author) :

Misoprostol in labour induction of term pregnancy: a meta-analysis.
Chin Med J (Engl). 2004 Mar;117(3):449-52.

Résumé (français) :

Abstract (English):

OBJECTIVE: To evaluate the efficacy and safety of misoprostol in term labour induction.

DATA SOURCES: Data from published English and Chinese literatures about misoprostol in term labour induction were identified from Medline and CBMdisk (using the search terms "misoprostol" and "labour induction") before 2001; hand searches of reference lists of original studies and reviews (including meta-analyses) and contact with investigators in this field before 2001.

STUDY SELECTION: Studies were included if they had data on misoprostol and labour induction. Altogether 623 articles were found and 124 were admitted, including 19,287 cases.

DATA EXTRACTION: Data were collected on efficacy and incidence of side-effects of misoprostol and oxytocin. Data were checked for consistency within the published articles and converted into a standard format for incorporation into a central database.

DATA SYNTHESIS: The average successful induction rate, rates of caesarean section; incidence of tachysystole, hypertonus of uterus and precipitous labour, and rates of meconium stained amniotic fluid between the misoprostol and oxytocin groups were significantly different (P < 0.05). There were no significant differences between the two groups concerning the average interval from the administration of misoprostol and oxytocin to the onset of labour, duration of the total stage of labour, incidence rate of foetal distress, neonatal asphyxia (1-minute Apgar score < and= 7), postpartum haemorrhage or amount of blood loss in postpartum.

CONCLUSIONS: Misoprostol is a superior agent over oxytocin on the induction of term labour, but its application might increase the risk of precipitous labour, abnormal uterine contractions or meconium stained amniotic fluid. Therefore, the dosages and regimens of the agent need further investigation.

Sumário (português):

URL :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1504379

Comments :

Argument (français) :


Argument (English):

Argumento (português):

Keywords :

c-section/caesarean ; induction of labor ; fetal distress ; duration of labour ; postpartum hemorrhage ; evidence-based medicine/midwifery ; misoprostol (Cytotec) ; oxytocin ; post-term pregnancy

Author of this record :

C. Loup

New expert query ---  New simple query

Creating new record

This database is managed by Alliance francophone pour l'accouchement respecté (AFAR, http://afar.info)
affiliated with Collectif interassociatif autour de la naissance (CIANE, http://ciane.net).
It is fed by the voluntary contributions of persons interested in the sharing of scientific data.
If you agree with this project, you can support us in several ways:
(1) becoming a member of AFAR
(2) financially supporting AFAR
(3) contributing to this database if you have a minimum training in scientific documentation.