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Database - Alliance francophone pour l'accouchement respecté (AFAR)

Record ID : 640
Created on : 13/04/2004
Modified on : 2/12/2007

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URL of this record : http://afar.info/id=640

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Author(s) :

Chong YS, Chua S, Shen L, Arulkumaran S.

Year of publication :


Bibliographical entry (without author) :

Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. Review.
European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;113(2):191-198.

Résumé (français) :

Abstract (English):

OBJECTIVE: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes.

STUDY DESIGN: Fifty women were given misoprostol 400 g either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1 ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters.

RESULTS: Uterine activity produced by oral solution misoprostol 400 g was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively).

CONCLUSION: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects.

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Argumento (português):

Keywords :

induction of labor ; duration of labour ; active management of labor ; postpartum hemorrhage ; evidence-based medicine/midwifery ; misoprostol (Cytotec) ; post-term pregnancy

Author of this record :

C. Loup

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