Choose your font:
 Mukta Malar
 Open Sans Condensed
 Source Sans Pro


[Valid RSS] RSS

Database - Alliance francophone pour l'accouchement respecté (AFAR)
Created on : 13/04/2004
Modified on : 2/12/2007

Modify this record
Do not follow this link unless you know an editor’s password!


Author(s) :

Chong YS, Chua S, Shen L, Arulkumaran S.

Bibliographical entry (without author) :

Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. Review.
European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;113(2):191-198.

Year of publication :


Résumé (français) :

Abstract (English):

OBJECTIVE: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes.

STUDY DESIGN: Fifty women were given misoprostol 400 g either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1 ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters.

RESULTS: Uterine activity produced by oral solution misoprostol 400 g was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively).

CONCLUSION: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects.

Sumário (português):


Comments :

Argument (français) :

Argument (English):

Argumento (português):

Keywords :

induction of labor ; duration of labour ; active management of labor ; postpartum hemorrhage ; evidence-based medicine/midwifery ; misoprostol (Cytotec) ; post-term pregnancy

Author of this record :

Cécile_Loup — 13/04/2004

DateDiscussion (only in English)Author
➡ Only identified users

 I have read the guidelines of discussions and I accept all terms (read guidelines)

New expert query ---  New simple query

Creating new record --- Importing records

User management --- Dump database


This database is managed by Alliance francophone pour l'accouchement respecté (AFAR,
affiliated with Collectif interassociatif autour de la naissance (CIANE,
It is fed by the voluntary contributions of persons interested in the sharing of scientific data.
If you agree with this project, you can support us in several ways:
(1) becoming a member of AFAR
(2) financially supporting AFAR
(3) contributing to this database if you have a minimum training in scientific documentation.
Sign in or create an account to follow changes or become an editor.
Contact afar.association(arobase) for more information.

Valid CSS! Valid HTML!