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Database - Alliance francophone pour l'accouchement respecté (AFAR)
Created on : 8/10/2004
Modified on : 2/12/2007

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Author(s) :

Lumbiganon P, Villar J, Piaggio G, Gulmezoglu AM, Adetoro L, Carroli G.

Bibliographical entry (without author) :

Side effects of oral misoprostol during the first 24 hours after administration in the third stage of labour.
BJOG. 2002 Nov;109(11):1222-6.

Year of publication :


Résumé (français) :

Abstract (English):

OBJECTIVE: To evaluate the side effects of 600 microg misoprostol orally during the first 24 hours after administration in the third stage of labour. DESIGN: Double blind randomised controlled trial.

SETTING: Tertiary care hospitals in Nigeria and Thailand.

SAMPLE: All women participating in the WHO Misoprostol trial in these two hospitals between January 1, 1999 and June 17, 1999.

METHODS: All women were followed up during the first 24 hours postpartum to evaluate the occurrence of shivering, nausea, vomiting, diarrhoea and other misoprostol-related side effects.

MAIN OUTCOME MEASURES: Rates of shivering, nausea, vomiting, diarrhoea and pyrexia within 1 hour and in the intervals 2-6, 7-12, 13-18 and 19-24 hours after delivery.

RESULTS: A total of 1686 women were enrolled. Women who received misoprostol had higher incidence than the oxytocin group of 'any' shivering in the first hour (RR 6.4, 95% CI 3.9 to 10.4) and the period covering 2-6 hours following delivery (RR 4.7, 95% CI 1.9 to 11.2). Pyrexia was also more common in the misoprostol group in both the same time intervals (RR 2.8, 95% CI 1.4 to 5.3 and RR 6.3, 95% CI 3.7 to 10.8, respectively). Diarrhoea was not present in the first hour in either group but appeared in the second time period (2-6 hours) and third time period (7-12 hours) more frequently in the misoprostol group than with oxytocin.

CONCLUSION: The increased incidence of shivering and pyrexia that occurs with postpartum use of misoprostol persists up to 6 hours following delivery. Approximately 5% of women experience diarrhoea that starts after 1 hour and subsides within 12 hours.

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Keywords :

postpartum hemorrhage ; evidence-based medicine/midwifery ; oxytocin ; hormones ; active management of labor ; duration of labour

Author of this record :

Cécile_Loup — 8/10/2004

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