![]() | Banco de dados - (CIANE) |
Descrição deste banco de dados documental (Site da CIANE) |
https://ciane.net/id=2812 | ➡ Modificar esta ficha ![]() ![]() |
Nota bibliográfica (sem autor) : | Vaginal misoprostol for cervical ripening and induction of labour. - Cochrane database of systematic reviews (Online) - N°10 |
Autores : | Hofmeyr, G.J.; Gülmezoglu, A.M.; Pileggi, C. |
Ano de publicação : | 2010 |
URL(s) : | |
Résumé (français) : |
|
Abstract (English) : | Misoprostol (Cytotec, Searle) is a prostaglandin E1 analogue widely used for off-label indications such as induction of abortion and of labour. This is one of a series of reviews of methods of cervical ripening and labour induction using standardised methodology. To determine the effects of vaginal misoprostol for third trimester cervical ripening or induction of labour. The Cochrane Pregnancy and Childbirth Group’s Trials Register (November 2008) and bibliographies of relevant papers. We updated this search on 30 April 2010 and added the results to the awaiting classification section. Clinical trials comparing vaginal misoprostol used for third trimester cervical ripening or labour induction with placebo/no treatment or other methods listed above it on a predefined list of labour induction methods. We developed a strategy to deal with the large volume and complexity of trial data relating to labour induction. This involved a two-stage method of data extraction.We used fixed-effect Mantel-Haenszel meta-analysis for combining dichotomous data.If we identified substantial heterogeneity (I 2 greater than 50%), we used a random-effects method. We included 121 trials. The risk of bias must be kept in mind as only 13 trials were double blind.Compared to placebo, misoprostol was associated with reduced failure to achieve vaginal delivery within 24 hours (average relative risk (RR) 0.51, 95% confidence interval (CI) 0.37 to 0.71). Uterine hyperstimulation, without fetal heart rate (FHR) changes, was increased (RR 3.52 95% CI 1.78 to 6.99).Compared with vaginal prostaglandin E2, intracervical prostaglandin E2 and oxytocin, vaginal misoprostol was associated with less epidural analgesia use, fewer failures to achieve vaginal delivery within 24 hours and more uterine hyperstimulation. Compared with vaginal or intracervical prostaglandin E2, oxytocin augmentation was less common with misoprostol and meconium-stained liquor more common.Lower doses of misoprostol compared to higher doses were associated with more need for oxytocin augmentation and less uterine hyperstimulation, with and without FHR changes.We found no information on women’s views. Vaginal misoprostol in doses above 25 mcg four-hourly was more effective than conventional methods of labour induction, but with more uterine hyperstimulation. Lower doses were similar to conventional methods in effectiveness and risks. The authors request information on cases of uterine rupture known to readers. The vaginal route should not be researched further as another Cochrane review has shown that the oral route of administration is preferable to the vaginal route. Professional and governmental bodies should agree guidelines for the use of misoprostol, based on the best available evidence and local circumstances. |
Sumário (português) : | |
Resumen (español) : |
|
Comentários : | |
Argument (français) : |
|
Argument (English): |
|
Argumento (português): | |
Argumento (español): |
|
Palavras-chaves : | ➡ indução ; amadurecimento do colo do útero ; misoprostol (Cytotec) ; aborto |
Autor da esta ficha : | Import 26/11/2017 — 26 Nov 2017 |
Discussão (exibir todas as linguas) | ||
---|---|---|
Efectuar uma nova consulta especialista --- Outro pedido simples
Gerenciamento de usuários --- Fazer backup do banco de dados --- Contato
Esta base de dados criada pela Alliance francophone pour l'accouchement respecté (AFAR) é gerida
pela Collectif interassociatif autour de la naissance (CIANE, https://ciane.net).
Ele é alimentado pelas contribuições de voluntários interessados em compartilhar informações científicas.
Se você aprovar este projeto, você pode nos ajudar de várias maneiras:
(1) tornar-se um colaborador com base nisso, se você tem um pouco experiência na literatura científica
(2) ou apoio financeiro CIANE (veja abaixo)
(3) ou tornar-se um membro da outra associação afiliada à CIANE.
➡ Faça login ou crie uma conta para seguir as alterações ou se tornar um editor.
➡ Contato bibli(arobase)ciane.net para mais informações.
Doar para a CIANE (clique em “Faire un don”) nos ajudará a manter e desenvolver sites e bancos de dados públicos para o apoio das decisões informadas dos pais e cuidadores com relação ao parto |